National Toxicology Program Updates Data, Tools for Chemical Characterization

An updated version of the Integrated Chemical Environment was released last month by the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The Integrated Chemical Environment comprises data sets curated from NICEATM and its partners as well as computational tools intended to help assess chemical safety and contextualize data. It also provides chemical safety data and property predictions.

According to NICEATM, the latest version of the Integrated Chemical Environment features harmonized skin sensitization and eye irritation data and updated principal component analysis plots in its Chemical Characterization tool, which can be used to explore and compare properties and chemical use categories for one or two chemical lists. The updated Integrated Chemical Environment also provides expanded options for users to provide input data for two other tools: the In Vitro to In Vivo Extrapolation tool, which “uses pharmacokinetic models to predict the equivalent administered dose … from the activity concentration of selected assays,” and the Physiologically Based Pharmacokinetics tool, which allows users to “generate predictions of tissue-specific chemical concentration profiles following a dosing event.” Users will also find an updated Toxicology in the 21st Century (Tox21) “Chemical Quick List,” which can be used to quickly populate a query. This list includes more than 9,000 chemicals tested in the Tox21 program.

Users can access the Integrated Chemical Environment via the website of the National Toxicology Program and read release notes summarizing the recent changes.